Publications

Recent publications

Ganga A.K.*, Sweeney L.S.*, Rubio Ramos A., Wrinn C.M., Bishop C.S., Hamel V., Guichard P., Breslow D.K. (2024). A disease-associated PPP2R3C-MAP3K1 phospho-regulatory module controls centrosome function. Current Biology, 34(20):4824-4834.e6. Also published on bioRxiv (https://doi.org/10.1101/2024.04.02.587836).
Bruel A.-L.^#, Ganga A.K., Nosková L., Valenzuela I., Martinovic J., Duffourd Y., Zikánová M., Majer F., Kmoch S., Mohler M., Sun J., Sweeney L.K., Martínez Gil N., Thauvin-Robinet C., Breslow D.K.^# (2023) Pathogenic RAB34 variants impair primary cilium assembly and cause a novel oral-facial-digital syndrome. Human Molecular Genetics. 32(18): 2822-2831. https://doi.org/10.1093/hmg/ddad109.
Ganga A.K., Kennedy M.C., Oguchi M.E., Gray S.D., Oliver K.E., Knight T.A., De La Cruz E.M., Homma Y., Fukuda M., Breslow D.K. (2021). Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway. Current Biology, 31(13):2895-2905.e7. Also published on bioRxiv (http://doi.org/10.1101/2020.10.29.360891).
Breslow D.K.^# and Holland A.J.^# (2019). Mechanism and regulation of centriole and cilium biogenesis. Annual Reviews in Biochemistry, 88: 691-724. [ePub ahead of print Jan 2 2019] [review article].
Breslow D.K. (2018). Pericentrin Knocks Down Cilia in Trisomy 21, Developmental Cell, 46(5): 527-8.
Breslow D.K.^#,*, Hoogendoorn S.^*, Kopp A.R., Morgens D.W., Vu, B.K., Kennedy, M.C., Han K., Li A., Hess G.T., Bassik M.C., Chen J.K.^#, Nachury M.V.^# (2018). A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies, Nature Genetics, 50(3): 460-71. Also published as bioRxiv 156059, http://doi.org/10.1101/156059.

Prior publications

Breslow D.K.^# and Nachury M.V.^# (2015). Analysis of Soluble Protein Entry into Primary Cilia Using Semipermeabilized Cells, Methods in Cell Biology, 127: 203-21.
Liew G.M., Ye F., Nager A.R., Murphy J.P., Lee J.S., Aguiar M., Breslow D.K., Gygi S.P, Nachury M.V. (2014) The Intraflagellar Transport Protein IFT27 Promotes BBSome Exit from Cilia through the GTPase ARL6/BBS3, Developmental Cell, 31(3): 265-78.
Breslow D.K., Koslover E.F., Seydel F., Spakowitz A.J., Nachury M.V. (2013). An In Vitro Assay for Entry into Cilia Reveals Unique Properties of the Soluble Diffusion Barrier, Journal of Cell Biology. 203(1): 129-49.
Ye F., Breslow D.K., Koslover E.F., Spakowitz A.J., Nelson W.J., Nachury M.V. (2013). Single Molecule Imaging Reveals a Major Role for Diffusion in the Exploration of Ciliary Space by Signaling Receptors, eLife. 2: e00654.
Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C., (2011). A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. PLoS Genetics, 7(11): e1002358.
Breslow D.K. and Nachury M.V., (2011). Primary Cilia: How to Keep the Riff-Raff in the Plasma Membrane. Current Biology. 21(11): R434-436.

Breslow D.K., (2013). Sphingolipid homeostasis in the endoplasmic reticulum and beyond. In The Endoplasmic Reticulum. S. Ferro-Novick, T.A. Rapoport, R. Schekman, editors. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY. 207-222.
Roelants F.M.*, Breslow D.K.*, Muir A., Bodenmiller B., Weissman J.S., Thorner J.T., (2011). Protein Kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA, 108(48): 19222-7.
Breslow D.K. and Weissman J.S., (2010). Membranes in Balance: Mechanisms of Sphingolipid Homeostasis. Molecular Cell. 40(2): 267-279. [review article].
Breslow D.K., Collins S.R., Bodenmiller B., Aebersold R., Simons K., Shevchenko A., Ejsing C.S., Weissman J.S., (2010). Orm Family Proteins Mediate Sphingolipid Homeostasis. Nature. 463(7284): 1048-1053.
Breslow D.K.*, Cameron D.M.*, Collins S.R., Schuldiner M., Stewart-Ornstein J., Newman H.W., Braun S., Madhani H.D., Krogan N.J., Weissman J.S., (2008). A Comprehensive Strategy Enabling High-Resolution Functional Analysis of the Yeast Genome. Nature Methods. 5(8): 711-718.
Newman J.R., Ghaemmaghami S., Ihmels J., Breslow D.K., Noble M., DeRisi J.L., Weissman J.S. (2006). Single-cell Proteomic Analysis of S. cerevisiae Reveals the Architecture of Biological Noise. Nature, 441(7095): 840-846.