Welcome

Welcome to the Breslow lab in the Department of Molecular, Cellular & Developmental Biology at Yale University

  • We use functional genomic tools to dissect biological processes at the cellular and molecular level.
  • Our main focus is the mammalian primary cilium, a cellular structure that serves as a signal transduction center in development and disease.
  • Combining new screening technologies with biochemical reconstitution and cell-based microscopy assays, we are pursuing a range of questions at the interface of organelle biology, signal transduction and cell cycle control.

News

November 20, 2025
Our work on a platform for pooled microscopy-based CRISPR screening is published in Developmental Cell. We are excited about this technology and discovery of new ciliary...
October 29, 2025
Excited to share a paper led by Shane Elliott, using a CRISPRa screen to identify a new cilia disassembly pathway and connection to focal cortical dysplasia, a neurological...
March 7, 2025
We are excited to welcome new PhD students Deniz Seven and Hailey Fiel!